Intermetatarsal bursitis identified in clinically suspect arthralgia

About one-quarter of patients with clinically suspect arthralgia (CSA) have intermetatarsal bursitis (IMB), which is often accompanied by subclinical synovitis and tenosynovitis, according to a study published online Nov. 13 in Rheumatology. Bastiaan T. van Dijk, from the Leiden University Medical Centre in the Netherlands, and colleagues performed a large magnetic resonance imaging (MRI) study […]

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FDA approves Livtencity for posttransplant cytomegalovirus

The U.S. Food and Drug Administration has approved the first drug for treating posttransplant cytomegalovirus (CMV) that has not responded to available antiviral treatments, the agency announced Tuesday. Livtencity (maribavir) prevents the activity of human cytomegalovirus enzyme pUL97, thereby blocking virus replication. The drug is indicated for patients ages 12 years and older (weighing at […]

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Research shows why immune checkpoint blockade impedes but does not stop glioblastoma progression

Like locking the door but opening windows, an immune checkpoint therapy temporarily slows glioblastoma (GBM) progression but fails to establish an effective anti-tumor microenvironment and appears to increase molecular interactions inhibiting long-term immune response, according to studies led by a UCLA research team. In the Nov. 26 issue of Nature Communications, the researchers explain why […]

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A new phenotype of LRP6 mutation

A group led by Prof. Han Dong of Peking University School of Stomatology reported for the first time hand preaxial polydactyly in patients with tooth agenesis carrying a previously unknown mutation of low-density lipoprotein receptor-related protein 6 (LRP6). The study was published November 10 in NPJ Genomic Medicine. In the study, the researchers performed whole-exome […]

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Novel system invented for preventing cardiovascular diseases, non-invasively

Cardiovascular diseases (CVDs) are the leading cause of death globally. Monitoring of lipid in patients with coronary heart disease (CHD) is important for decreasing the incidence of cardiovascular events. The traditional indicator, Low-density lipoprotein cholesterol (LDL-C), is prone to false positives in specific conditions, while invasive routine blood lipid detection fluctuates with the influence of […]

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